Systems Genetics - linking genotypes and phenotypes

Systems Genetics Cover

Florian Markowetz and Michael Boutros (eds.)
Cambridge University Press
July 2015

Whereas genetic studies have traditionally focused on explaining heritance of single traits and their phenotypes, recent technological advances have made it possible to comprehensively dissect the genetic architecture of complex traits and quantify how genes interact to shape phenotypes.

This exciting new area has been termed systems genetics and is born out of a synthesis of multiple fields, integrating a range of approaches and exploiting our increased ability to obtain quantitative and detailed measurements on a broad spectrum of phenotypes.

"Since the completion of the Human Genome Project we hold the "book of life" in our hands, but for the most part, we do not understand how to interpret it. We lack an understanding of the grammar that it is written in. With this book the authors put together an impressive collection of chapters that provide insights into our current efforts to understand how genetic information is integrated, coordinated and ultimately assembled into biological systems. If you are interested in how to decipher the grammar of life this is a must read!" says Frank Buchholz, TU Dresden, Germany

Gathering the contributions of leading scientists, both computational and experimental, this book shows how experimental perturbations can help us to understand the link between genotype and phenotype. A snapshot of current research activity and state-of-the-art approaches to systems genetics are provided, including work from model organisms such as Saccharomices cerevisiae, Drosophila melanogaster, as well as from human studies.

Systems genetics

Researchers and graduate students in genetics, functional genomics, bioinformatics, computational biology, systems biology, and biotechnology will find this title a valuable and timely resource.

Table of contents

  1. An introduction to Systems Genetics
    F Markowetz and M Boutros
  2. Computational paradigms for analyzing genetic interaction networks
    Pons et al
  3. Mapping genetic interactions across many phenotypes in metazoan cells
    Laufer et al
  4. Genetic interactions and network reliability
    E Delgado-Eckert and N Beerenwinkel
  5. Synthetic lethality and chemoresistance in cancer
    K Max eld and A Whitehurst
  6. Joining the dots - network analysis of gene perturbation data
    Xin Wang, Ke Yuan, Florian Markowetz
  7. High Content Screening in Infectious Diseases: new drugs against bugs
    AP Mäurer, PR Braun, K Holden-Dye, TF Meyer
  8. Inferring genetic architecture from systems genetics studies
    X Sun, S Mohr, A Vinayagam, P Hong N Perrimon
  9. Bayesian inference for model selection: An application to aberrant signalling pathways in chronic myeloid leukaemia
    L Hopcroft, B Calderhead, P Gallipoli, T Holyoake and M Girolami
  10. Dynamic network models of protein complexes
    Y Park and JS Bader
  11. Phenotype state spaces and strategies for exploring them
    Andreas Hadjiprocopis and Rune Linding
  12. Automated behavioural fingerprinting of C. elegans mutants
    Andre E.X. Brown and William R. Schafer


Systems Genetics @ CUP

Free chapter

Download the first chapter "An introduction to Systems Genetics" from the CUP website.


The authors are leading experts in the field and include
  • Joel Bader
  • Niko Beerenwinkel
  • Charlie Boone
  • Mark Girolami
  • Rune Linding
  • Thomas Meyer
  • Chad Myers
  • Norbert Perrimon
  • William Shafer

From the editors

We have written this book because Systems Genetics is a broad and interdisciplinary field. Every day we are working with researchers from diverse backgrounds ranging from mathematics to biochemistry. We wanted to write a book that unites different view points and shows how synergies between disciplines contribute to linking genotypes and phenotypes. We are very excited about the result and the collection of contributors we could assemble.